Analytical Development (AD)
The Analytical Development team are on hand to ensure that client projects have any development work required for titre development - PCR, ELISA, Flow. Alternatively, clients can tech transfer in their own assays. Working in harmony with PD, AD aims to focus on:
- Characterizing yields (empty: full ratios, via genomic and capsid titre)
- Characterizing and controlling impurities (HCD, HCP)
- Introduction of modern analytical platforms including ELISA, PCR, Blots
- Supporting client projects with analytical assay development
- Transfer to QC for product batch release
The GTVF has an in-house QC team who support the production and process development teams throughout client project lifecycles. The QC team is looking to transition from manual methodologies to automated, thereby reduce human error, improve efficiency and reduce operating time. Some examples of automation include the below:
- ELLA (automated) for ELISA,
- Cell counters for cell counting,
- Introducing a nucleic acid extraction instrument (QIACube Connect),
- dPCR using QIAcuity One.
