Process Development (PD) and MSAT

Process Development (PD)

The Process Development team is dedicated to the continuous development of process. The team is on hand to support requested client process development work alongside Production and Quality, and is focused on developing our own platform process, with a particular focus on:

• Innovating the next generation of processing, (e.g. use of suspension cells and an animal component free system)
• Upstream optimisation (e.g. adopting new technology, evaluating improved cell lines, optimising transfection methodology)
• Downstream optimisation (e.g. filtration and purification optimisation)
• Improving efficiency and reliability to deliver higher productivity batches to enable larger clinical studies
• Enabling process control systems for better consistent output: clarification, bioreactors, chromatography, TFF systems
• Developing single use and closed loop processes

Manufacturing Science & Technology (MSAT)

The MSAT group are instrumental in driving improvement into delivery processes. They work in collaboration with our process development scientists, manufacturing production teams and our clients to achieve continuous improvements in the way that we manufacture viral vector. This 4-person team works closely with the other teams to ensure that the new processes and equipment are deployed to optimise activity at GTVF.